Artemis is one of the easier bosses in Devil May Cry 5, but she can still be tricky if you don’t know how to read her attack patterns. By understanding her telegraphed moves, optimal counters, and the best weapons for each character, you can take her down quickly and efficiently. This guide will break down each phase of the fight, best weapons and styles, and optimal dodging techniques to secure a flawless victory.

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1. Understanding Artemis’s Attack Patterns

Artemis signals her attacks through her wings, allowing you to anticipate and dodge effectively:

• Middle Wings Active → Bullet Line Attack
  • Lower Arms Crossed (X Shape) → Vertical bullet lines (top-to-bottom or bottom-to-top).
  • Lower Arms Unmoved → Horizontal bullet lines (left-to-right or right-to-left).
• Top Wings Active → Bullet Rain Attack
  • Bullets track you initially but lock onto a fixed position before firing.
• Bomb Spawn Attack
  • Artemis releases tracking bombs with weak tracking—they can be dodged easily by simply walking away or destroyed with attacks.

Best Dodge Strategy: Jump diagonally upward regardless of bullet line direction—this consistently avoids damage.

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2. Artemis’s Phases & How to Counter Them

Phase 1 – Standard Attack Cycle

• Stay airborne and use jump cancels to avoid ground-based bullet lines.
• Close in for air combos and dodge bombs when they appear.
• Warning: When white dots appear around Artemis, she’s about to scream and knock you back—use Enemy Step to dodge.

Phase 2 – Wing Detachment & Bullet Hell Mode

• At 75% health, Artemis sends out floating energy cores (or “boobs”) that fire bullets or rings.
• Destroy them ASAP before they flood the arena with projectiles.
• Once damaged, the cores turn blue—use Snatch (Nero) to grab them and ride them to close the distance.

Phase 3 – Charge Attacks & Nuke Attempt

• At 50% health, Artemis begins charging across the arena 1–3 times.
• Use Buster (Nero) mid-flight to grab and counter.
• Artemis will attempt a large-scale nuke—jump away from the red-marked ground.
• After the nuke, Artemis releases a pair of docile cores, which can be used as grapple points.
• Final Knockdown: Once stunned, Artemis becomes vulnerable to Buster (Nero) or Royal Guard releases (Dante).

Pro Tip: Nero can time his Exceed inputs during the Buster grab to charge his attacks!

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3. Best Weapons & Styles for Each Character

Nero’s Best Moves Against Artemis

✅ Air Rave + Calibur – Primary aerial offense.
✅ Showdown + Buster – Devastating finisher when Artemis is stunned.
✅ Overture (Battery Attack) – Quick burst damage against energy cores.
✅ Punchline (Breakage Rocket Punch) – Good for constant damage output.
✅ Gerbera (Dodging Utility) – Provides easy bullet line evasion.

Pro Tip: Avoid using Punchline to counter the nuke—it doesn’t result in a proper knockdown.

Dante’s Best Moves Against Artemis

✅ Air Trick (Teleporting Close) – No need for grapple points.
✅ Royal Guard Release – Can block Artemis’s charge attack.
✅ Coyote-A (Shotgun Stuns) – One of the fastest ways to stagger Artemis.
✅ Cavalier B (Air Combo B) – Highest hit-stun weapon for Artemis.
✅ Sin Devil Trigger (SDT) – Use it when available for heavy burst damage.

Pro Tip: Balrog’s Real Impact is NOT optimal here, as its final hit often fails to connect.

V’s Best Moves Against Artemis

✅ Griffon’s Electric Attacks – Effective against airborne Artemis.
✅ Skewer (Nightmare’s Laser) – Best for breaking energy cores.
✅ Save One DT Bar for Royal Fork – Clears all energy cores instantly.
✅ Shadow’s Melee Attacks – If positioned correctly, can land good damage.

Pro Tip: V should let Griffon do most of the work and use Nightmare strategically.

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4. Advanced Strategies & Efficient Kill Setups

• Punchline’s Rocket Ride grants immunity to horizontal bullet lines, making it useful for long-range mobility.
• Overture Bomb Stacking: Use multiple overture bombs in a row for explosive burst damage.
• Gerbera’s Petal Ray (Ground Breakage) offers consistent, safe ranged damage.
• Tomboy’s Stash Tag + Jump Cancel inflicts high DPS if executed properly.
• Rawhide’s Stun Potential: Not ideal for speed kills but offers decent stagger buildup.
• Ragtime Breakage (Slow Down Effect) can interrupt Artemis’s bullet spam.

Final Tip: If using Nero, air rave, caliber, showdown, and buster are all you need to win.

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5. Summary of Key Strategies

✅ Jump diagonally upwards to dodge all bullet line attacks.
✅ Destroy energy cores ASAP to prevent bullet hell scenarios.
✅ Use Snatch (Nero) or Air Trick (Dante) to close the gap quickly.
✅ Counter Artemis’s charge attacks with Buster (Nero) or Royal Guard (Dante).
✅ Avoid using Real Impact spam—Cavalier B is the best weapon for Artemis.
✅ Use Royal Fork (V) to clear energy cores instantly.

By following this guide, you’ll defeat Artemis effortlessly, avoid unnecessary damage, and secure your S-Rank victory. Now go out there and show her what real style looks like!