Hey guys, what’s up, Eelin here! In today’s Warframe guide, I’ll teach you how to efficiently run Netra Cell missions to farm Archon Shards, Melee Arcanes, and Melee Arcane Adapters.

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Unlocking Netra Cell Missions

First, complete the Whispers in the Walls quest. After that:

• Go to Deimos and enter the Sanctum Anatomica.
• Fast travel to Tager, the goat-cat-looking NPC.
• Access Netra Cells from his dialogue.

Each week, you can run Netra Cell missions up to five times. Rewards include:

• Archon Shards (Crimson, Azure, Amber)
• Melee Arcanes
• Melee Arcane Adapters

Enemies in these missions range from level 220 to 240 and have various scaling debuffs and restrictions:

• Increased health and shield scaling per squad member
• Only allies can revive you
• 3-minute cooldown on restores
• Cannot summon anything

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Beginner-Friendly Loadout

If you’re new, here’s a recommended setup:

Warframe: Rhino

• High ability strength & duration
• Iron Skin and Roar for survival & damage
• Optional: Subsumed Shock with Shock Trooper mod or Ironclad Charge augment

Weapons:

• Primary: Sporothrix with viral/heat setup
• Secondary: Any high-damage AoE
• Melee: Zaw or Zorus for quick CC with electric damage

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Key Mechanics and Strategy

• You’ll collect 4 debuff keys that weaken your Warframe.
• Solo players must carry all four. In squads, each player takes one.
• Hack terminals to locate the vault, insert a key to activate it.
• Clear enemies in a defined zone to lower security and access the vault.

Efficient Enemy Clearing:

• Nautilus Sentinel with Cordon mod to group enemies
• Operator Mod: Magus Anomaly for enemy grouping when using transference

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Recommended Warframes for Efficiency

1. Styanax:

• Great AOE and armor stripping
• Use Final Stand augment for overguard on Javelin hits

2. Dante:

• Ability spam nuking via Dark Verse and Tragedy
• Replace first ability with Roar for increased damage

3. Wukong (Speedrun Build):

• Cloud Walker for fast vault and terminal access
• Immortality from passive
• Melee-centric build with Dual Ichor & Melee Influence
• Use Magus Anomaly and Nautilus for crowd control

Recommended Arcanes & Mods:

• Melee Influence (spread melee damage)
• Primary/Secondary Dexterity (for combo duration)
• Explosive weapon (e.g., Aegrit) for drone phases

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Drone Phase

• Around 67-75% progress, a drone spawns
• Use explosive weapons to quickly clear it

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Fastest Run Showcase

• Sub-6 minute solo run using Wukong + Dual Ichor
• Skip terminal hacking if you memorize vault spawns
• Use operator transference + melee spam to rapidly eliminate groups
• Focus on Eximus units first

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Rewards & Final Steps

• After clearing the vault, collect rewards:
  • Unidentified item
  • Two Inodilant resources
• Check reward upon extraction

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Final Thoughts

This guide covers both beginner and advanced strategies for Netra Cell missions. Choose your preferred Warframe and optimize based on your goals: speed, safety, or pure nuking.